Prof. Dr. Maja Köhn

Prof. Dr. Maja Köhn Institute of Biology III Group: Integrative Signalling Studies  www.bioss.uni-freiburg.de Phone: +49 (0)761 203-67900 maja.koehn@bioss.uni-freiburg.de

Focus of research

• Biology and pathology of phosphatases
• Chemical tools to study phosphatases

CV

• Since 2018 Vice Dean, Faculty of Biology, University of Freiburg
• Since 2018 Steering committee member of the excellence cluster CIBSS Centre for Integrative Biological Signaling Studies, University of Freiburg
• Since 2018 Vice speaker BIOSS Centre for Biological Signaling Studies, University of Freiburg
• Since 2016 Full Professor Integrative Signalling Research, Faculty of Biology, Albert-Ludwigs-Universität, Freiburg
• 2007-2016 Group Leader at the European Molecular Biology Laboratory, Heidelberg
• 2005-2007 Postdoctoral fellow with Prof. G. L. Verdine at the Department of Chemistry and Chemical Biology, Harvard University, USA
• 2002-2005 Dr. rer. nat. in Organic Chemistry, Technical University Dortmund and MPI for Molecular Physiology, supervisor: Prof. H. Waldmann
• 1996-2001 Diploma in Chemistry, Christian-Albrechts-University of Kiel

Selected publications

• Y. Wang, B. Hoermann, K. Pavic, M. Trebacz, P. Rios, M. Köhn (2019)  Interrogating PP1 activity in the MAPK pathway with optimized PP1-disrupting peptides. ChemBioChem. 20, 66-71.
• T.H. Fischer, J. Eiringhaus, N. Dybkova, A. Saadatmand, S. Pabel, S. Weber, Y. Wang, M. Köhn, T. Tirilomis, S. Ljubojevic, A. Renner, J. Gummert, L.S. Maier, G. Hasenfuß, A. El-Armouche, S. Sossalla (2018) Activation of protein phosphatase 1 by a selective phosphatase disrupting peptide reduces sarcoplasmic reticulum Ca2+ leak in human heart failure. Eur J Heart Fail. 20, 1673-1685.
• P. Luján, G. Varsano, T. Rubio, M.L. Hennrich, T. Sachsenheimer, M. Gálvez-Santisteban, F. Martín-Belmonte, A.C. Gavin, B. Brügger, M. Köhn. J (2016) Phosphatase of regenerating liver (PRL)-3 disrupts epithelial architecture by altering the post-mitotic midbody position. Cell Sci.129, 4130-4142.
• M. Fontanillo, I. Zemskov, M. Häfner, U. Uhrig, F. Salvi, B. Simon, T. Wittmann, M. Köhn (2016) Synthesis of Highly Selective Submicromolar Microcystin-Based Inhibitors of protein phosphatase (PP)2A over PP1. Angew. Chem. Int. Ed. 55, 13985-13989.
• X. Li, M. Wilmanns, J. Thornton, M. Köhn (2013) Elucidating human phosphatase-substrate networks. Sci Signal. 6, rs10.
   

[Link to compete publication list]