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Prof. Dr. Matthias Boll


Prof. Dr.
Matthias Boll

Institut of Biologie II

Group: Metabolic biochemistry of microorganisms

Phone: +49 (0)761 203-2649



Focus of research

  • Anaerobic microbial degradation of pollutants
  • Energetic coupling in microbial metabolism
  • Function and application of microbial biocatalysts


  • 2008-2014 Coordinator of DFG Priority Program 1319: “Biological transformation of hydrocarbons without oxygen: from the molecular to the global scale”
  • Since 2002 Full professor (W3) for microbial biochemistry, Faculty of Biology, ALU Freiburg
  • 2006-2012 Full professor (W2) for Metabolic biochemistry, Institute of Biochemistry, University of Leipzig, Leipzig
  • 1998-2006 Associate and assistant professor, University of Freiburg
  • 2002 Habilitation (ALU Freiburg)
  • 1997-1998 Postdoctoral fellow with Prof. D.Lowe, John Innes Centre, Norwich, UK
  • 1993-1996 PhD (Universities Ulm/Freiburg)
  • 1992 Diploma studies in Biology ALU Freiburg 

Selected publications

  • Huwiler, S.G. Löffler, C., Anselmann, S.E.L., Stärk, H.-J., von Bergen, M., Flechsler, J., Rachel, R. & Boll, M. (2019) One megadalton metalloenzyme complex in Geobacter metallireducens involved in benzene ring reduction beyond the biological redox window. Proc Natl Acad Sci, doi.org/10.1073/pnas.1819636116
  • Jacoby C, Eipper J, Warnke M, Tiedt O, Mergelsberg M, Stärk HJ, Daus B, Martín-Moldes Z, Zamarro MT, Díaz E, Boll M. (2018)Four Molybdenum-Dependent Steroid C-25 Hydroxylases: Heterologous Overproduction, Role in Steroid Degradation, and Application for 25-Hydroxyvitamin D3 Synthesis. MBio. pii: e00694-18.
  • Ebenau-Jehle C, Mergelsberg M, Fischer S, Brüls T, Jehmlich N, von Bergen M, Boll M. (2017) An unusual strategy for the anoxic biodegradation of phthalate. ISME J 11:224-236
  • Warnke M, Jung T, Dermer J, Hipp K, Jehmlich N, von Bergen M, Ferlaino S, Fries A, Müller M, Boll M (2016) 25-hydroxyvitamin D3 synthesis by enzymatic steroid side-chain hydroxylation with water. Angew Chem Int Ed Engl 55:1881-4.
  • Weinert, T., Huwiler, S.G., Kung, J.W., Weidenweber, S., Hellwig, P., Biskup, T., Weber, S., Cotelesage, J.H., George, G.N., Ermler, U and Boll, M. (2015) Structural basis of enzymatic benzene ring reduction. Nature Chem Biol 11, 586-591


[Link to complete publication list]

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