Prof. Dr. Maja Köhn
Prof. Dr. |
Focus of research
- Biology and pathology of phosphatases
- Chemical tools to study phosphatases
CV
- Since 2021 Speaker of the BIOSS Centre for Biological Signaling Studies, University of Freiburg
- Since 2019 Steering committee member of the excellence cluster CIBSS Centre for Integrative Biological Signaling Studies, University of Freiburg
- Since 2018 Vice Dean, Faculty of Biology, University of Freiburg
- Since 2018 Vice speaker BIOSS Centre for Biological Signaling Studies, University of Freiburg
- Since 2016 Full Professor Integrative Signalling Research, Faculty of Biology, Albert-Ludwigs-Universität, Freiburg
- 2007-2016 Group Leader at the European Molecular Biology Laboratory, Heidelberg
- 2005-2007 Postdoctoral fellow with Prof. G. L. Verdine at the Department of Chemistry and Chemical Biology, Harvard University, USA
- 2002-2005 Dr. rer. nat. in Organic Chemistry, Technical University Dortmund and MPI for Molecular Physiology, supervisor: Prof. H. Waldmann
- 1996-2001 Diploma in Chemistry, Christian-Albrechts-University of Kiel
Selected publications
- B. Hoermann, T. Kokot, D. Helm, S. Heinzlmeir, J.E. Chojnacki, T. Schubert, C. Ludwig, A. Berteotti, N. Kurzawa, B. Kuster, M.M. Savitski, M. Köhn (2020) Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A. Nat. Commun. 2020, 11, 3583.
- Y. Wang, B. Hoermann, K. Pavic, M. Trebacz, P. Rios, M. Köhn (2019) Interrogating PP1 activity in the MAPK pathway with optimized PP1-disrupting peptides. ChemBioChem. 20, 66-71.
- P. Luján, G. Varsano, T. Rubio, M.L. Hennrich, T. Sachsenheimer, M. Gálvez-Santisteban, F. Martín-Belmonte, A.C. Gavin, B. Brügger, M. Köhn. J (2016) Phosphatase of regenerating liver (PRL)-3 disrupts epithelial architecture by altering the post-mitotic midbody position. Cell Sci.129, 4130-4142.
- M. Fontanillo, I. Zemskov, M. Häfner, U. Uhrig, F. Salvi, B. Simon, T. Wittmann, M. Köhn (2016) Synthesis of Highly Selective Submicromolar Microcystin-Based Inhibitors of protein phosphatase (PP)2A over PP1. Angew. Chem. Int. Ed. 55, 13985-13989.
- X. Li, M. Wilmanns, J. Thornton, M. Köhn (2013) Elucidating human phosphatase-substrate networks. Sci Signal. 6, rs10.