Jun.-Prof. Dr. Khaled Selim

Jun.-Prof. Dr. Khaled Selim Institute of Biology II Group: Molecular Physiology of Prokaryotes rb.gy/gkir8x Phone: +49 (0)761 203-2638 khaled.selim@biologie.uni-freiburg.de

Focus of research

• Bacterial cell signaling (PII signal transduction superfamily and Second messengers signaling)
• Molecular and structural mechanisms for coordination central carbon and nitrogen metabolisms
• Regulation of membrane transporters
• Multicellularity and developmental processes of cyanobacteria

CV

• Since 2023 Junior Professor for Microbiology at the University of Freiburg
• 2020-2023 Group Leader at Organismic Interactions Department, University of Tübingen
• 2019-2023 Guest Scientist at Max-Plank Institute for Biology, Protein Evolution Department
• 2014-2019 PhD in Biology (summa cum laude) at Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen (DAAD scholarship)
• 2012-2013 Visiting Scholar at the Institute for Microbial and Biochemical Technology, Forest Products Laboratory, USDA, Madison, USA
• 009-2014 Research Assistant at the Chemistry of Natural and Microbial Products Department, National Research Centre, Cairo
• 2008-2012 Master of Science (Microbiology) at Cairo University
• 2004-2008 Bachelor of Science (Chemistry and Biology; double degree) at Cairo University

Selected publications

• Selim KA, Haffner M, Mantovani O, Albrecht R, Zhu H, Hagemann M, Forchhammer K, Hartmann MD. Carbon signaling protein SbtB possesses atypical redox-regulated apyrase activity to facilitate regulation of bicarbonate transporter SbtA. Proc Natl Acad Sci USA. 2023; 120(8):e2205882120. doi: 10.1073/pnas.2205882120.
• Mantovani O, Reimann V, Haffner M, Herrmann FP, Selim KA, Forchhammer K, Hess WR, Hagemann M. The impact of the cyanobacterial carbon-regulator protein SbtB and of the second messengers cAMP and c-di-AMP on CO2 -dependent gene expression. New Phytol. 2022; 234(5):1801-1816. doi: 10.1111/nph.18094.
• Selim KA, Haffner M, Burkhardt M, Mantovani O, Neumann N, Albrecht R, Seifert R, Krüger L, Stülke J, Hartmann MD, Hagemann M, Forchhammer K. Diurnal metabolic control in cyanobacteria requires perception of second messenger signaling molecule c-di-AMP by the carbon control protein SbtB. Science Advances. 2021; 7(50):eabk0568. doi: 10.1126/sciadv.abk0568.
• Selim KA, Tremiño L, Marco-Marín C, Alva V, Espinosa J, Contreras A, Hartmann MD, Forchhammer K, Rubio V. Functional and structural characterization of PII-like protein CutA does not support involvement in heavy metal tolerance and hints at a small-molecule carrying/signaling role. FEBS J. 2021; 288(4):1142-1162. doi: 10.1111/febs.15464.
• Selim KA, Lapina T, Forchhammer K, Ermilova E. Interaction of N-acetyl-l-glutamate kinase with the PII signal transducer in the non-photosynthetic alga Polytomella parva: Co-evolution towards a hetero-oligomeric enzyme. FEBS J. 2020 ; 287(3):465-482. doi: 10.1111/febs.14989.
• Selim KA, Haase F, Hartmann MD, Hagemann M, Forchhammer K. PII-like signaling protein SbtB links cAMP sensing with cyanobacterial inorganic carbon response. Proc Natl Acad Sci USA. 2018; 115(21):E4861-E4869. doi: 10.1073/pnas.1803790115.

[Link to complete publication list]