Prof. Dr. Michael Reth

Prof. Dr. Michael Reth Institute of Biology III Group: Molecular Immunology www.bioss.uni-freiburg.de michael.reth@bioss.uni-freiburg.de

Focus of research

• Structure and function of the B cell antigen receptor
• Signalling processes during B cell development and activation
• Synthetic biology and functional rebuilding of signalling circuits

CV

• Since 2019 Foreign member of the National Academy of Sciences
• Since 2007 Scientific director of the BIOSS Centre for Biological Signalling Studies funded by the excellence program of the German government
• Since 1996 Full Professor in Molecular Immunology, University of Freiburg
• 1989-1996 Associate Professor (C3), MPI for Immunobiology, Freiburg
• 1985-1988 Group Leader, Institute of Genetics, University of Cologne
• 1982-1985 Postdoctoral Fellow (DFG), Columbia University, New York
• 1977-1981 PhD studies (Immunology/Genetics), University of Cologne
• 1971-1977 Diploma studies (Biology), University of Cologne

Selected publications

• Gold, M. and M. Reth(2019). "Antigen Receptor Function in the Context of the Nanoscale Organization of the B Cell Membrane." Annu. Rev. Immunol. 37: 97-123.
• Kulathu, Y., C. Zuern, J. Yang and M. Reth (2018). "Synthetic biology of B cell activation: understanding signal amplification at the B cell antigen receptor using a rebuilding approach." Biol Chem
• Maity PC, Blount A, Jumaa H, Ronneberger O, Lillemeier BF, Reth M. (2015). B cell antigen receptors of the IgM and IgD classes are clustered in different protein islands that are altered during B cell activation. Sci Signal 15 (8) (394):ra93.
• Klaesener K, Maity PC, Hobeika E, Yang J, Reth M. (2014). B cell activation involves nanoscale receptor reorganizations and inside-out signaling by Syk. Elife 3: e02069.
• Yang, J., and Reth, M. (2010). Oligomeric organization of the B-cell antigen receptor on resting cells. Nature 467(7314): 465-469.
   

[Link to complete publication list]