6. Februar 2020: Giuseppe Locatelli, Theodor Kocher Institute (TKI), Universität Bern
Vortrag im Biologischen Kolloquium: "Dynamics of phagocytes during central nervous system autoimmune inflammation"
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| Wann |
06.02.2020 von 16:15 bis 17:30 |
| Wo | Hörsaal Zoologie, Institut für Biologie I, Hauptstraße 1 |
| Name | Jeanette Molloy |
| Termin übernehmen |
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Abstract
The Central Nervous System (CNS) parenchyma is protected by a multilayered system of biological barriers, functionally separating glia and neurons from peripheral circulation. Within these borders and inside the tissue parenchyma, long-lived CNS-resident microglia/macrophages regulate organ homeostasis as dynamic observers. During pathological conditions however, inflammation drastically increases CNS complexity by driving the recruitment of blood-borne monocyte-derived cells across distinct local gateways. Through a remarkable phenotypic plasticity, these cells can guide both the detrimental and the remission phases of the disease, but how this phenotype evolution happens at a population and single-cell level is only partially understood. Furthermore, the mechanism of compartment-specific invasion remains unclear.
Our laboratory combines 2-photon imaging in animal models of neuroinflammation with primary cultures of in vitro CNS barriers, altogether aiming at unravelling the invasion gateways used by polarized and non-polarized phagocytes. Moreover, we are addressing the role of a somatotrophic hormone, Insulin-like Growth factor 1, as master regulator of phagocyte functions during neuroinflammation.