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Prof. Dr. Pitter Huesgen


Prof. Dr.
Pitter Huesgen

Institute of Biology II

Group: Biochemistry and Functional Proteomics

Phone: +49 (0)761 203-2690



Focus of research

  • Proteomics method development
  • Protease substrate identifcation
  • Proteolysis in cellular stress responses


  • Since 2023, W3 Professor for Biochemistry (Functional Proteomics), Faculty of Biology
  • 2019-2023, W2 Professor for Protein Dynamics and Proteolysis at CECAD, Medical Faculty, University of Cologne
  • 2014-2023, Team leader at the Central Institute for Engineering, Electronics and Analytics, Forschungszentrum Jülich
  • 2008-2014, Postdoc and Research Associate at the Centre for Blood Research, University of British Columbia, Vancouver, Canada
  • 2003-2007, PhD studies in plant biochemistry, University of Konstanz

Selected publications

  • Barghahn S#, Saridis G#, Mantz M#, Meyer U, Mellüh JC, Misas Villamil JC, Huesgen PF*, Doehlemann G* (2023) Combination of transcriptomic, proteomic and degradomic profiling reveals common and distinct patterns of pathogen-induced cell death in maize. The Plant Journal. 116:574-596. doi: 10.1111/tpj.1635
  • Demir F*, Kizhakkedathu JN, Rinschen MM, Huesgen PF* (2021) MANTI: Automated Annotation of Protein N-Termini for Rapid Interpretation of N-Terminome Data Sets. Analytical Chemistry 93:5596-5605.
  • Hofsetz E, Demir F, Szczepanowska K, Kukat A, Kizhakkedathu J, Trifunovic A*, Huesgen PF* (2020) The mouse heart mitochondria N terminome provides insights into ClpXP-mediated proteolysis Molecular and Cellular Proteomics 19:1330-1345.
  • Weng SSH, Demir F, Ergin EK, Dirnberger S, Uzozie A, Tuscher D, Nierves L, Tsui J, Huesgen PF*, Lange PF* (2019) Sensitive determination of proteolytic proteoforms in limited microscale proteome samples. Molecular and Cellular Proteomics 18:2335-2347.
  • Huesgen PF, Lange PF, Rogers LR, Solis N, Eckhard U, Kleifeld O, Gomis-Rüth XF, Overall CM (2015) LysargiNase mirrors trypsin for protein C-termini and methylation site identification. Nature Methods 12, 55-8.

(# shared first, * shared corresponding authors)


[Link to complete publication list]

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