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Prof. Dr. Susana Minguet


Prof. Dr.
Susana Minguet

Institute of Biology III

Group: Lymphocyte signaling

Phone: +49 (0)761 203-67514



Focus of research

  • The nano-organization of the plasma membrane in T and B lymphocytes
  • Understanding T cells activation to develop translational and synthetic applications to improve T-cell immunotherapies against cancer


  • 2019 Associated researcher of the Cluster of Excellence CIBSS, Centre for Integrative Biological Signalling Studies
  • 2018 Habilitation in Immunology; University of Freiburg
  • 2017 Member of the Cluster of Excellence BIOSS, Centre for Biological Signalling Studies
  • 2016 Member of the Center of Chronic Immunodeficiency (CCI)
  • Since 2011 Group Leader in the Department of Immunology, University of Freiburg, Faculty of Biology (Freiburg, Germany)
  • 2008-2011 Ramón & Cajal Fellow (Centro Nacional de Investigaciones Cardiovasculares Carlos III · CNIC (Madrid, Spain)
  • 2003-2007 Postdoc, Max Planck-Institute for Immunobiology and Epigenetics (Freiburg, Germany)
  • 1997-2002 PhD degree in Sciences (Biochemistry and Molecular Biology). Universidad Autónoma de Madrid (UAM) Spain
  • 1992-1997 Degree in Chemical Sciences (Biochemistry and Molecular Biology). Universidad Autónoma de Madrid (UAM) Spain

Selected publications

  • Fiala GJ, Minguet S. 2018. Caveolin-1: The Unnoticed Player in TCR and BCR Signaling. Adv Immunol. 137:83-133.
  • Minguet S§, Kläsener K, Schaffer AM, Fiala GJ, Osteso-Ibánez T, Raute K, Navarro-Lérida I, Hartl FA, Seidl M, Reth M, Del Pozo MA. 2017. Caveolin-1-dependent nanoscale organization of the BCR regulates B cell tolerance. Nat Immunol. 10:1150-1159. §Corresponding author.
  • Schamel WW, Alarcon B, Höfer T, Minguet S. 2017. The Allostery Model of TCR Regulation. J Immunol. 1:47-52.
  • Swamy, M, Beck-Garcia, K, Beck-Garcia, E, Hartl, FA, Morath, A, Yousefi, OS, Dopfer, EP, Molnar, E, Schulze, AK, Blanco, R, Borroto A, Martín-Blanco N, Alarcon B, Höfer T, Minguet S§ and Schamel WWA§. 2016. A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation. Immunity 44:1091-1101. §Shared corresponding author.
  • Schönle A, Hartl FA, Mentzel J, Rauch KS, Wohlfeil SA, Nöltner T, Hechinger AK, Melchinger W, Fehrenbach K, Guadamillas MC, Prestipino A, Follo M, Prinz G, Ruess AK, Pfeifer D, Pozo MA, Schmitt-Graeff A, Duyster J, Blazar BR, Schachtrup K, Minguet S§ and Zeiser R§. 2016. “Caveolin-1 regulates TCR signal strength and regulatory T cell differentiation into alloreactive T cells” Blood 15:1930-9. §Shared corresponding author. 


[Link to complete publication list]

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