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Prof. Dr. Wolfgang W. Schamel


Prof. Dr.
Wolfgang W. Schamel

Institute of Biology III

Group: Immunology

Phone: +49 (0)761 203-67511



Focus of research

  • Molecular mechanisms of T cell activation
  • Cancer immunotherapy
  • Optogenetics


  • since 2010 Full Professor for Immunology
  • 2008-2010 Group Leader, Max Planck Institute for Immunobiology, Freiburg
  • 2002-2008 Emmy Noether Group Leader, Max Planck Institute for Immunobiology, Freiburg
  • 2000-2002 Postdoc at the Centro de Biologia Molecular „Severo Ochoa“, Madrid, Spain
  • 1995-1999 PhD thesis in Molecular Immunology, University Freiburg
  • 1988-1994 Diploma studies in Biochemistry, Free University Berlin and Weizmann Institute, Rehovot, Israel

Selected publications

  • Schamel WW, Alarcon B, Hofer T, Minguet S (2017) The Allostery Model of TCR Regulation. J Immunol 198: 47-52
  • Swamy M, Beck-Garcia K, Beck-Garcia E, Hartl FA, Morath A, Yousefi OS, Dopfer EP, Molnar E, Schulze AK, Blanco R, Borroto A, Martin-Blanco N, Alarcon B, Hofer T, Minguet S, Schamel WW (2016) A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation. Immunity 44: 1091-1101
  • Wang F, Beck-Garcia K, Zorzin C, Schamel WW, Davis MM (2016) Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol. Nat Immunol 17: 844-850
  • Dopfer EP, Hartl FA, Oberg HH, Siegers GM, Yousefi OS, Kock S, Fiala GJ, Garcillan B, Sandstrom A, Alarcon B, Regueiro JR, Kabelitz D, Adams EJ, Minguet S, Wesch D, Fisch P, Schamel WW (2014) The CD3 Conformational Change in the gammadelta T Cell Receptor Is Not Triggered by Antigens but Can Be Enforced to Enhance Tumor Killing. Cell Reports 7: 1704-1715
  • Minguet S, Swamy M, Alarcon B, Luescher IF, Schamel WW (2007) Full activation of the T cell receptor requires both clustering and conformational changes at CD3. Immunity 26: 43-54


[Link to complete publication list]

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